Abstract
T CD8 lymphocytes play critical role in controlling infection by some neurotrophic virus by dependent mechanisms of perforin and granzymes, FasL-Fas, or by the production of antiviral cytokines such as IFN-³ or TNF-±. Granzyme B induce apoptosis and DNA fragmentation into target cells. T CD8 cells participate in the eradication of infected cells by West Nile virus, whereas athymic mice ex…