Abstract
Necroptosis is a recently discovered, biochemically-controlled, cell death pathway that is independent of caspases and present morphological hallmarks similar to those of accidental necrosis. It can be activated by different stimuli, including death receptors and TRIF-mediated signals, and involves sequential phosphorylation of RIPK1 and RIPK3 kinases as well the MLKL pseudokinase. The ro…