Abstract
Nanostructured Lipid Carriers as a Platform for the Delivery of Artepillin C and Brazilian Green Propolis: Overcoming the Blood-Brain Barrier in in vitro and in vivo Glioblastoma Models (AU)
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Wallance Moreira Pazin
CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de Bauru. Faculdade de Ciências (FC) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Bachelor in Biological Physics (2006 - 2009), UNESP/IBILCE, Master (2010 - 2012) and Doctor (2012 - 2016), USP/FFCLRP in Sciences by the Applied Physics to Medicine and Biology program, with an internship abroad at the University of Southern Denmark (Odense-Denmark) and Eindhoven University of Technology (Eindhoven-Netherlands). Postdoctoral: FFCLRP/USP (2016) FCT/UNESP (09/2016 08/2020), University of Southern Denmark (04/2018 - 03/2019) and USP/IFSC (02/2021 - 08/2022). Assistant Professor at the Department of Physics and Meteorology at the Faculty of Sciences, UNESP, Bauru campus, accredited in the Institutional Graduate Program of UNESP in Science and Technology of Materials (POSMAT). Researcher PQ level 2 of CNPq. Develops research in the formulation and characterization of nanostructured lipid systems for carrying Brazilian propolis bioactives in tumor cells and in biomimetic models of cell membranes, using spectroscopic and microscopic techniques, in addition to exploring the luminescent properties of new compounds with theranostic potential. At the same time, he works in a line of research aimed at developing nanobiosensors with an immunoassay strategy for antigen detection using surface-amplified Raman scattering spectroscopy (SERS) and machine learning. (Source: Lattes Curriculum)
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Research grants
Scholarships in Brazil
- Development of an electrochemical biosensor based on carbon-fiber antibody as a strategy for hipogonadism diagnosis., BP.IC
Abstract
This study aims to identify possible causes of hypogonadism through electrochemical biosensors, focusing on the diagnosis of diseases associated with testosterone deficiency. The goal is to develop a faster and less invasive diagnostic method, with potential commercial applications in the pharmaceutical industry. Due to the rarity of hypogonadism, early diagnosis is crucial, as its sympto…
- Implications of the surface charge of lipid nanoparticles curcumin carriers in giant unilamellar vesicles used as membrane models, BP.IC
Abstract
Bioactive natural compounds are known for their therapeutic potential, however, there is a major limitation in the clinical use of most of these compounds due to the low efficiency of absorption and bioavailability when administered orally or topically in vivo, as is the case of curcumin, a derivative compound from Curcuma longa, popularly known as turmeric. It is known that there is a hi…
- Photophisical properties of alizarin and its potential use as a photosensitizer in photodynamic therapy, BP.IC
Abstract
Bioactive natural compounds stand out for their therapeutic potentials, with some capable of absorbing light, making them candidates for targeted and non-invasive therapies, such as photodynamic therapy (PDT). In this approach, a photosensitizer (PS) is biologically administered and activated by light, resulting in the production of reactive oxygen species, potentially selectively damagin…
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Scholarships abroad
- Interaction of Green Propolis Compounds and Nanostructured Lipid Carriers with Supported Lipid Bilayers: A SRS Microscopy Approach, BE.EP.IC
Abstract
This international research internship project aims to investigate how nanostructured lipidcarriers (NLCs), with and without encapsulated Artepillin C or green propolis extract,influence the organization and phase behavior of supported lipid bilayers (SLBs). ArtepillinC, the main active compound in Brazilian green propolis, presents low solubility andbioavailability, challenges that have …
- Insights on the interaction of Artepillin C with tumor cell membranes: an advanced fluorescence microscopy study, BE.EP.PD
Abstract
Artepillin C is the major constituent of green propolis, one of the most consumed products in folk medicine. It has been reported that Artepillin C displays, among several therapeutic effects, antitumor activity, especially due to the presence of two prenylated groups in its structure, believed to enhance access to the cell membrane. However, membrane outer leaflet of tumor cells is expos…