Abstract
In sickle cell anemia (SCA), leukocyte plays an important role in the pathophysiology of disease, and leukocyte adhesion may in fact be the initiating event in vaso-occlusive episodes. The neutrophil appears to be the leukocyte that most participates in the vaso-occlusive process, at least in sickle mice, although mononuclear cells and eosinophils probably also contribute. Preliminary res…