Has experience in General Biology (Source: Lattes Curriculum)
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Medulloblastoma (MB) is a solid malignant tumour of the central nervous system (CNS) located in the cerebellum, which most affects and kills children. The prognosis and survival rate of patients with MB vary according to molecular subgroups: SHH (Sonic Hedgehog), which represents about 30% of cases, separated into tumours with mutated or wild-type TP53 gene; WNT (Wingless), which correspo…
The serine protease TMPRSS11A (DESC3), belonging to the newly discovered family HAT / DESC serine transmembrane protease type II (TTSPII) is deleted / mutated in, respectively, 4% of cervical cancers and 2% of cancers mouth (obtained cBioPortal database). However, little is known about this enzyme. However, in John P. Hobson et al. (JBC Papers, 2004) observed that the serine protease TMPR…
Medulloblastoma (MB) is the most common malignant central nervous system (CNS) tumor in children, with molecularly diverse subgroups that influence prognosis and therapeutic response. Despite advancements in treatment, long-term survivors often face significant challenges, including endocrine complications, cognitive deficits, and debilitating long-term side effects. Relapse and chemoresi…
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