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Universidade Federal do ABC (UFABC). Centro de Ciências Naturais e Humanas (CCNH) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Aline Cristina Parletta in research grants and scholarships supported by FAPESP.
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Hypothyroidism is a highly prevalent disease that affects different systems in the body. In the heart, hypothyroidism causes bradycardia, diastolic dysfunction, atrophy, and cardiac fibrosis. In the kidneys, hypothyroidism impairs the blood filtration capacity, causing renal atrophy and fibrosis. Cardiac and renal dysfunctions are closely related and this relationship is currently defined…
Long-term hypothyroidism is associated with cardiac fibrosis (due to neutrophil infiltration) and ventricular dilation, which can culminate in heart failure. Studies show that HTs deficiency leads to an increase in inflammatory markers, such as C-Reactive Protein (CRP), TNF-alpha, IL-6 and GFR-beta1 and the restoration to a condition of euthyroidism, although it promotes improvement in ca…
Cardiac hypertrophy, despite being an adaptive response may contribute to cardiomyopathy development and progression. It is well established that thyroid hormones exert direct and indirect effects on the heart, which result on an hypertrophic state of this organ. In this sense, our research group has been studying the various cellular and molecular mechanisms involved in this process. Rec…
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