Abstract
Hydrogen sulfide (H2S) is a gaseous mediator endogenously produced in mammals mainly by the enzymes cystathionine ³-lyase enzyme (CSE) and cystathionine-²-synthase (CBS) using L-cysteine as substrate. A recent work from our laboratory shows that H2S donors, such as the compound GYY-4137 (slow release) or NaHS (spontaneous release), have anti-nociceptive and antiinflammatory effects on the…