Abstract
It is known that human ESCs and iPSs require bFGF but not LIF while murine ESCs and iPS require LIF but not bFGF for the maintenance of pluripotency in vitro. The "naïve" stage is represented by the pre-implantation embryo cell mass, exemplified by the murine ESCs, and the primed stage by the post-implantation epiblast and human ESCs (Nichols & Smith 2009; Ware et al., 2014). In iPS of ot…