Abstract
The endothelial cells produce and release relaxing dependent endothelial factors (EDRFs) and contractile factors. The major EDRF is nitric oxide (NO) that is produced by endothelial nitric oxide synthase (eNOS). Uncoupled eNO produces oxygen reactive species (ROS). eNOS can be expressed as dimer (active enzyme) or monomer (inactive enzyme). NO donors can release NO in the endothelial cell…