Abstract
Prostaglandin E2 (PGE2) is important in the process of hypothalamic sexual differentiation, promoting masculinization of the hypothalamus of males. Non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen (the third class of medications most commonly used by pregnant women) act through the non-selective inhibition of the enzyme cyclooxygenase (COX-1 and COX-2), leading to a reduc…