Abstract
Hematopoietic stem cells may acquire mutations that confer a replicative advantage, leading to the expansion of the mutated cell, the so-called clonal hematopoiesis. Somatic mutations that give rise to clonal hematopoiesis are rare in the first four decades of life but increase in frequency with aging, affecting mainly three genes: DNMT3A, TET2 e ASXL1. These genes are also frequently mut…