Abstract
This study aims to assess the pharmacokinetics-pharmacodynamics of rifampin, isoniazid, pyrazinamide and ethambutol in macrophages derived from human THP-1 monocyte lineage infected and not infected with strains of Mycobacterium tuberculosis H37Rv. Pharmacokinetic and pharmacodynamic (PK-PD) data of antibiotics in macrophages will be included to population pharmacokinetic model in plasma …