Abstract
CAF1 (CCR4-NOT-associated factor), also known as CNOT7, is a component of the eukaryotic CCR4-NOT complex that regulates not only the synthesis but also the destruction of mRNAs in the cell. CAF1 is conserved from yeast to man and it presents deadenylase activity upon the poli(A) tail of mRNAs. Thus, CAF1 plays an essential role in gene regulation through an mRNA decay mechanism. In a pre…