Abstract
In a ER stress scenario, Nox4 expression and ROS-producing activity are increased, accounting, in a context-specific way, for either survival or apoptosis (Pedruzzi et al, 2004; Santos et al, 2009; Wu et al, 2010). The specific signaling pathways triggered by Nox4 in this situation are poorly known. ER stress is associated with the accumulation of un/misfolded proteins and toxic lipids wi…