Bachelor in Biological Sciences (2021) from FCAV/UNESP, Master in Biosciences with an emphasis on Genetics and Evolutionary Biology (2024) from (IBILCE/UNESP with an exchange period held at Maastricht University - Netherlands. Currently is PhD student in Cellular and Molecular Biology on Faculty of Medicine of Ribeirão Preto, University of São Paulo (FMRP/USP). He carries out his research project in the area of #8203;#8203;Mitochondrial Biology. working with Drosophila melanogaster. (Source: Lattes Curriculum)
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The mitochondria's electron transport system (ETS) complexes, notably I, III and IV, can organize themselves into supramolecular structures called supercomplexes (SCs). SCs appear to be capable of facilitating electron flow during oxidative phosphorylation (OXPHOS) and reducing the formation of reactive oxygen species (ROS). Furthermore, in conjunction with ATP synthase dimers, SCs contri…
The mitochondrial alternative oxidase (AOX) is naturally absent in vertebrates and insects, but present in tunicates like Ciona intestinalis. The xenotopic expression of C. intestinalis AOX in Drosophila melanogaster and mice has shown promising results for the combat of mitochondrial dysfunction, exhibiting a potential therapeutic use in the future. AOX is a mitochondrial inner membrane…
Genetic, metabolic or physiological disorders that affect the mitochondrial respiratory chain cause depletion of cellular ATP levels and excessive formation of reactive oxygen species (ROS). The xenotopic expression of the mitochondrial alternative oxidase (AOX) has been considered a possible therapy to prevent excess ROS formation by the respiratory chain in pathological conditions, with…
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