, acting on the following subjects: oxidade alternativa,. (Source: Lattes Curriculum)
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More than 30 mutations have been described in the human TWNK gene, which encodes the Twinkle mitochondrial replicative helicase. These mutations have heterogeneous clinical consequences, but generally affect the neurolocomotor system. Autosomal dominant progressive external ophthalmoplegia (adPEO), often caused by mutations in TWNK, is a late-onset neuromuscular disorder in which patients…
Dysfunctions in the respiratory chain complexes may cause increase of reactive oxygen species that damage the genetic and structural material of the cell. The alternative oxidase (AOX) allows electron flow from the ubiquinone directly to molecular oxygen, bypassing complexes III and IV and causing beneficial effects in organisms with malfunctions in such enzymes. When expressed in Drosoph…
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