Abstract
NHE-1 (Na+/H+ exchanger isoform 1), a member of a large family of integral membrane proteins, is found virtually in all tissues and cells of mammals and is necessary for many physiological processes. By regulating intracellular pH, NHE-1 contributes for the actin filament reorganization. The activity of NHE-1 is regulated by extracellular signals mediated by diverse classes of cell surfac…