Abstract
Trypanosoma cruzi is the only trypanosomatid pathogenic to humans that contains the complete pathway that converts Histidine (His) to Glutamate (Glu). According to the classical literature, this pathway is composed of four enzymes: His ammonia lyase (HAL), Urocanate Hydratase (UH), Imidazolone Propionase (IP) and Formiminoglutamase. However, the literature has also shown that one of the i…