Abstract
Sickle Cell Disease is a hematological disease characterized by a punctual mutation in the sixth codon of the ²-globin gene, responsible for the substitution of thymine for adenine (GAG to GTG). The discovery that butyrates promote increased production of fetal hemoglobin (HbF) by inhibiting histone deacetylases (HDACs) provides a new perspective of research on new drugs for treating this…