Abstract
Different tumor cells present a metabolic reprogramming characterized by the switch of the main energy pathway (oxidative phosphorylation) to glycolysis, even in the presence of sufficient oxygen, denominated the Warburg effect. Pyruvate dehydrogenase kinase (PDK) plays a role in this metabolic reprogramming, due to its inhibitory action on the pyruvate dehydrogenase complex, diverting th…