Abstract
Amyotrophic lateral sclerosis (ALS) is a progressive and lethal neuromuscular degenerative disease that affects 0.01% (~10/100,000) of the population worldwide. Most ALS patients (familial or sporadic) display a progressive motor disorder after the disease onset; therefore, characterizing it as a degenerative syndrome triggered by a major disruption of the neuromuscular axis. However, ~50…