Abstract
Tuberculosis (TB) is an infectious disease caused by the bacillus Mycobacterium tuberculosis that persists as one of the major public health problems. The only vaccine to date against tuberculosis is Calmette-Guérrin Bacillus (BCG), a live attenuated vaccine of the pathogenic strain Mycobacterium bovis. Molecular analyzes demonstrate a deletion of large non-genomic fragments of BCG strain…