Abstract
Several studies have shown that Crotoxin (CTX), the major toxin of the Crotalus durissus terrificus Venom (CdtV), has anti-inflammatory and immunomodulatory actions in vivo and in vitro. As regards immuno-modulatory activities, CTX stimulates, particularly, the metabolism of macrophages and the production of cytokines, lipoxin A4 and analogue 15-Epi-LXA4, by these cells, leading to inhibi…