CV Lattes
ORCID
Abstract
During the development of Type 1 Diabetes (T1D) pancreatic islets are invaded by immune cells which directly or via secretion of pro-inflammatory cytokines lead to pancreatic ² cells dysfunction and dead. In vitro exposure of ² cells to pro-inflammatory cytokines, such as IL-1², TNF and IFN-³ lead to dysfunction and apoptosis. The transcription factor NF-ºB has an important role in these …