CV Lattes
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Universidade Estadual de Campinas (UNICAMP). Instituto de Química (IQ) (Institutional affiliation from the last research proposal) Birthplace: Brazil
B.Sc. in Chemistry from Federal University of Espírito Santo (2011) and M.Sc. in Chemistry from Federal University of Espírito Santo (2013). PhD in Chemistry from Federal University of São Carlos (2017). Experience in Organic Chemistry, focusing on Organic Synthesis, acting on the following subjects: use of niobium catalysts in organic synthesis; organocatalysed asymmetric synthesis; multicomponent reactions; green chemistry; medicinal chemistry; design of new enzymatic inhibitors and inhibitory assays against cystein proteases. (Source: Lattes Curriculum)
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The work proposal for the postdoctoral fellowship involves collaboration with the Medicines for Neglected Diseases initiative (DNDi, www.dndi.org), a non-profit research and development organization that works to offer new treatments for neglected diseases, especially Chagas Disease, Leishmaniasis, Sleeping Sickness, filariasis, and Pediatric HIV. The aim of the project is to investigate …
Cysteine proteases provide targets useful for the treatment of various diseases that affect humans. In disorders caused by parasitic infection, cruzain is a target for enzymatic inhibition. The reactive and active catalytic cysteine site (Cys25) provides specificity for many inhibitors, but obtaining selectivity within families of cysteine proteases and their isoenzymes can be problematic…
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