Abstract
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder characterized by the progressive loss of motor neurons. Mostly, ALS is a sporadic disease, and only between 10 to 15% of the cases is familial (due to genetic reasons; named ALSf). Nowadays it is known that ALS etiology is multifactorial, since it does not only present changes in genic expression and an increase in ubiqui…