Abstract
Focal adhesions are essential for the cellular anchorage to extracellular matrix. Its formation depends on a redox-sensible signaling that involves de regulation of a number of enzymes, such as the activation of the focal adhesion kinase(FAK), by reactive oxygen species (ROS). In melanoma cells the main source of ROS is Nox4, a subtype of the NADPH oxidase. PDI is a thiol oxidase reductas…