Abstract
Epoxy-eicosatrienoic acids (EETs) are molecules of intracellular lipid signaling that have important biological activities, such as vasodilation, anti-inflammation and analgesic effects. However, EETs have a very short half-life since they are rapidly hydrolyzed by the soluble epoxy hydrolase enzyme (sEH), reducing their bioavailability. Thus, the inhibitors of the sEH enzyme arouse great…