Sabrina Mendes Botelho in research grants and scholarships supported by FAPESP.
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Pancreatic Cancer has high mortality rate according to the Brazilian National Cancer Institute (INCA). Gemcitabine is a drug usually applied in this case, but it has many limitations. Therefore, novel therapeutic alternatives are needed. Cysteine proteases present enormous physiopathological relevance, being overexpressed in many Cancer types, including the pancreatic adenocarcinoma. Amon…
Cysteine protease inhibitors have been described as cytostatic agents working as inhibitors of metastasis in many neoplasias, among them in pancreatic cancer cell lines. These cells overexpress cysteine proteases. In this Project, in vitro assays using the pancreatic cell line (MIA PaCa-2) and Balb/C 3T3 clone A31 mouse fibroblasts will be used to determine the selectivity profile for a s…
Cysteine cathepsin B and L (CTSB and CTSL) inhibitors present antineoplastic activity, as described in many reports in the literature. There is mounting evidence that these compounds could inhibit cancer progression and metastasis. Compounds 709 and 1031 are inhibitors of cysteine cathepsins, being cytotoxic to the pancreatic (MIA PaCa-2) cancer cells. Here, the mechanism of action for th…
| 1 / 1 | Ongoing scholarships in Brazil |
| 1 / 1 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 3 / 3 | All Scholarships |
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