Abstract
Periodontitis (P) and type 2 diabetes mellitus (T2DM) are complex and multifactorial chronic diseases, characterized by a hyper-inflammatory state. The immunoinflammatory state promotes the recruitment of specific cells that release mediators, such as interleukin-1² (IL-1²), IL-6, IL-7, tumor necrosis factor-alpha (TNF-±), and matrix metalloproteinases (MMPs). Therefore, the modulation of…