CV Lattes
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Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduated in Veterinary Medicine from the Federal University of Vale do São Francisco (UNIVASF) in 2012. Earned a Master's (2014) and Ph.D. (2018) in Pharmacology from the Federal University of Ceará (UFC). Completed a postdoctoral fellowship at the Research Center for Inflammatory Diseases (CRID) at the Ribeirão Preto Medical School (2022). Currently, he is a postdoctoral fellow at Brigham and Women's Hospital, Harvard Medical School. He has experience in pharmacology, immunology, and cell biology, with a focus on mechanisms of toxicity and resistance to cancer treatments, antitumor immunity, and metabolic interactions within the tumor microenvironment. (Source: Lattes Curriculum)
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The modulation of the immunological checkpoints with monoclonal antibodies anti-programmed cell death protein 1 (anti-PD-1), or anti-PD-1 ligand (anti-PD-L1) promotes the reactivation of antitumor immunity and produces unprecedented positive clinical responses in cancer treatment. However, 40-60% of patients presented a primary resistance to the anti-PD-1/PD-L1, which the mechanism is unk…
Although primary resistance to anti-PD1/PD-L1 inhibitors is a common clinical event, the biological pathways underlying mechanisms are not fully understood. Currently, the potential correlation between the tumor glycolytic metabolism reprogramming, known as Warburg effect, and primary resistance to immune checkpoint inhibitors (ICIs) remains unknown. We propose that tumors with high glyco…
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