Abstract
The intracellular concentration of the second cGMP and cAMP messengers is controlled by the rate of production through the activity of the enzymes soluble guanylate cyclase (GCs) and particulate or adenylate cyclase (AC), respectively and by clearance either by the action of phosphodiesterases or by the activity of the transporters of efflux. Transporters of the subtype MRP4 and MRP5 are …