CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Holds a bachelor's degree in Biological Sciences from the Adventist University Center of São Paulo UNASP (2019), a master's degree in Translational Medicine from the Federal University of São Paulo UNIFESP (2022), and is currently in the final year of a PhD at the Sepsis Research Laboratory at the Federal University of São Paulo UNIFESP, with a scholarship from FAPESP. (Source: Lattes Curriculum)
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AbstractSepsis is a public health problem that presents high morbidity and mortality, being one of the main causes of death in intensive care units. This condition, defined as a dysregulated host response to infection, has neutrophils as one of the first lines of defense against pathogens. Neutrophils are a priority in the lesion focus and even in adverse metabolic conditions they are cap…
Endotoxin tolerance is a phenomenon in which pre-exposure to LPS modulates the biological response to a re-exposure to high doses of LPS. It may represent a protective cellular mechanism to limit the inflammatory damage, to control excessive LPS-induced activation of monocytes and macrophages, and inhibit cytokine production (particularly TNF-±). The cell reprogramming observed in the end…
Sepsis is the leading cause of death in ICU and is defined as a dysregulated host response to infection, which causes organ dysfunction. Recent data indicate that septic patients present both immune suppression and inflammation simultaneously, so there is a modulation of the immune response. Several studies show the importance of energy metabolism in immune regulation, for example, differ…
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