Abstract
Epoxy-eicosatrienoic acids (EETs) are products of arachidonic acid metabolism catalyzed by epoxygenases of cytochrome P450. EETs have important biological activity, including anti-inflammatory, neuroprotective and neuromodulatory effects. EETs have a very short half-life since they are rapidly hydrolyzed by the enzyme soluble epoxy hydrolase (sEH), reducing their bioavailability. Thus, st…