Abstract
Abstract: The cardiac cycle depends on the proper function of the excitation contraction coupling in ventricular myocytes (VMs), which has ion channels as primary player present on cell membrane of VMs. Nav 1.5, encoded by SCN5A gene, is the primary cardiac sodium channel. Sodium current (INa) has two components: the transient peak (INa-P) and the late (INa-L). In the cardiac cycle, acqui…