Abstract
The endoplasmic reticulum (ER) stress consists of mechanisms related to the progressive decline beta cell function and mass in type 2 diabetes mellitus (DM2). The loss of ER homeostasis activates stress responses, the UPR (unfolded protein response), which can be induced, among other factors, by free fatty acids or inflammatory cytokines. Metformin is an antihyperglycaemic drug widely use…