Abstract
CD3 is a set of three protein chains associated with TCR±:² chains on the T lymphocytes membrane. The CD3 complex is essential for T cells activation and even for its the correct TCR expression. Anti-CD3 monoclonal antibodies (mAbs) have a great potential to treatment autoimmune diseases and induction of tolerance to allogeneic transplants. The original anti- CD3 mAb, produced by a murine…