CV Lattes
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Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas (FCF) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Pharmacist-Biochemist and PhD student in Pathophysiology and Toxicology at the Department of Clinical and Toxicological Analysis from the School of Pharmaceutical Sciences - University of São Paulo (FCF-USP). Interested in melanoma biology, and has experience in intellectual property, particularly in patents related to chemistry, pharmaceuticals, and biotechnology. Additionally, as undergraduate student researcher, developed the project: "The Role of PRX1 and PRX2 in Melanoma Tumor Heterogeneity" funded by FAPESP (2019-2020) and PROCAD-CAPES (2018-2019). (Source: Lattes Curriculum)
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Melanoma is the most lethal type of skin cancer, characterized by its high metastatic potential. The MAPK pathway, frequently activated by mutations in BRAF(V600E), plays a central role in its pathogenesis. Despite significant progress with BRAF inhibitors and immunotherapies, treatment resistance amplified by intra-tumoral heterogeneity underscores the urgent need for new biomarkers and …
Melanoma is the less common type of skin cancer, but it is the most aggressive. The most of patients harbor mutations in BRAF (V600E) protein, and its specific inhibitor vemurafenib has revolutionized the treatment of the disease. However, resistance to long-term therapy is recurrent, leading to treatment failure. Besides the acquired resistance, the many different mutations responsible f…
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