CV Lattes
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Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia (IB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduation at Ciências Biológicas from Universidade Estadual de Campinas (2022). , acting on the following subjects: hif-1#945;, macrophages, imunometabolismo, napdh-oxidase and immunometabolism. (Source: Lattes Curriculum)
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Pro-inflammatory macrophages, as those activated with LPS and INF-³ (³), are characterized by NF-ºB activation, pro-inflammatory cytokine induction (IL-1, IL-6, IL-12, TNF-±), and nitric oxide (NO) and reactive oxygen species (ROS) production. One source of ROS rapidly activated in phagocytes is NADPH-oxidase, regulated by NF-ºB, which directly controls gp91phox gene expression. M(LPS/³)…
Macrophages are essential cells for tissue homeostasis and constitute the first line of host defense. Macrophages activated with LPS and IFN-³ acquire a pro-inflammatory profile characterized by NF-kB activation, which in turn induces cytokine expression, such as IL-6, IL-1², and TNF-±, and the production of nitric oxide by inducible nitric oxide synthase (iNOS). To acquire this profile, …
The study of the functions of immune cells, such as macrophages, and their relationship with cellular metabolism has gained ground in the academic community. One of the targetmolecules related to macrophages metabolism is the transcription factor hypoxia induciblefactor 1 alpha (HIF-1alpha). Protein levels of HIF-1alpha are controlled by the von Hippel-Lindau factor (VHL), which signals H…
The recognition of bacterial components by macrophages triggers the production of inflammatory mediators, such as hydrogen peroxide (ROS), and cytokines, including TNF-a, IL-6, and IL-1b. This profile can be induced in macrophages activated with LPS plus IFN-a (M(LPS/y)) and depends on glucose metabolism and stabilization of hypoxia inducible factor-1a (HIF-1a). Glucose is necessary for N…
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