Abstract
In chronic kidney disease, both tubulointerstitial and glomerular sclerosis is observed. While the role of hypoxia in tubulointerstitial fibrosis is much studied, the glomerular lesion is less evaluated. Endothelial cells interact with the mesangial cells in the glomerulus, these cells produce extracellular matrix. This interaction, especially in deleterious conditions such as hypoxia, ca…