Abstract
The present project aims at the synthesis of (Z)-5-(4-fluorobenzylidene)thiazolidine-2,4-dione, an intermediate of the Active Pharmaceutical Ingredient Rosiglitazone, which is one of the anti-glycemic agents of the class of glitazones, used to treat diabetes mellitus type 2, an insulin sensitization substance for humans. The synthesis of this intermediate will be made through the reaction…