Abstract
Familial Hypercholesterolemia (FH) is an autosomal dominant disease that affects cholesterol metabolism and results in decreasing of LDL catabolism and increasing of its plasma concentration. FH phenotypes are consequence of variants in HF-related genes like Low-Density Lipoprotein Receptor (LDLR), APOliprotein B (APOB), and Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9). However, …