Abstract
Oral Squamous Cell Carcinoma (OSCC) is the most common head and neck malignant neoplasm, with high prevalence, severe morbidity, uncertain prognosis and a low five-year overall survival rate, between 40-50%. Excessive alcohol consumption is a prominent risk factor for OSCC. However, the initial stages of oral carcinogenesis guided by quiescent or non-activated fibroblasts, through the tra…