CV Lattes
ORCID
Abstract
The hypothalamic metabolism of glucose plays an important role in the central control of glycemia and food intake, aspects that are dysregulated in obesity and diabetes. In astrocytes, glucose metabolism generates pyruvate, which is converted to lactate by the enzyme lactate dehydrogenase A (LDH-A). The lactate is then transferred to neurons where it is reconverted to pyruvate by the enzy…