Abstract
Leptospirosis is a neglected zoonosis, endemic in developing countries with tropical or subtropical climate. Approximately one million new cases are reported yearly with 5-10% deaths. Some patients develop a clinical condition called Leptospirosis- associated Severe Pulmonary Hemorrhagic Syndrome (LPHS), with a mortality rate higher than 50%. The etiopathology of LPHS remains to be elucid…