graduation at Química from Universidade Federal de São Carlos (2020). (Source: Lattes Curriculum)
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Alzheimer's disease (AD) is characterized mainly by the accumulation of aggregates of beta-amyloid peptide (bA) in the patient's brain that lead to severe synaptic and cognitive dysfunctions not available in neurodegenerative dementia. Several studies indicate that bA toxicity comes from the process of aggregation and interaction with a neuronal membrane. Other studies suggest that non-am…
Our laboratory has been working on the development of luminescent complexes as teranostic agents for Alzheimer's disease. Recently, we prepared the luminescent complexes cis-[Ru(phen)2(Apy)]2+ (RuApy) in which phen = 1,10-phenanthroline and Apy = 4aminopyridine, 3,4-aminopyridine. For example, the complex containing the 3,4-Apy ligand is absorbed by neuronal cells reaching the cytoplasmic…
The neurotoxicity of oligomeric species of amyloid beta (OA²) peptide has been linked to damage caused to cell membranes by pore formation through interactions with cholesterol and ganglioside lipids. Consequently, studies of compounds that act directly on OA² at lipid membrane interfaces has enlarged considerably. Recently, we have demonstrated that the luminescent cis-[Ru(phen)2(3,4-Apy…
| 2 / 2 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 3 / 3 | All Scholarships |
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CV Lattes
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