Abstract
The human genome encodes three TRPML (Transient Receptor Potential cation channel, Mucolipin subfamily) proteins. These are evolutionarily related six-transmembrane, Ca2+-permeable, and non- selective cation channels that belong to the large family of Transient Receptor Potential (TRP) ion channels. The TRPML1 is thought to be involved in endo/lysosomal homeostasis and its malfunction is …