CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Master in General Sciences-Physiology at Institute of Biosciences of the University of São Paulo. He studied the impact of polyamines on the host-parasite interaction. Presentely is PhD student in Immunology Program at Institute of Biomedical Sciences- USP, as part of the research group in molecular biology, supervised by Dra. Sandra Marcia Muxel. He investigates the function of an long noncoding RNA during macrophage infection by Leishmania infantum, a pathogen that causes visceral leishmaniasis. (Source: Lattes Curriculum)
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In this project, we aim to evaluate the interaction of the Hypoxia inducible-factor 1a transcription factor (HIF-1a) and the long noncoding RNA HIF1A-AS3 and its role in glycolytic metabolism in macrophages infected with Leishmania infantum. We hypothesized that infection with L. infantum changes the oxygen supply and induces the gene expression of HIF-1± and the lncRNA encoded in the ant…
Mammalian host infected with protozoan parasite Leishmania amazonensis causes a cutaneous leishmaniosis, a neglected disease that present a higher prevalence in Brazil. The establishment of immunological response uses post-transcriptional resources, such as microRNAs, which are largely studied in leishmaniasis. The ways to forward the control of gene expression regulation from polyamines …
The relationship of long noncoding RNAs (lncRNAs) in the immunometabolic connections during Leishmania infection remains poorly tested. Here, we propose an integrative approach to study the function of lncRNA HIF1A-AS3 encoded in HIF1A antisense strand in the Leishmania-induced shifts in metabolic networks in murine macrophages, deciphering the molecular mechanisms of this phenomenon and …
| 2 / 2 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 3 / 3 | All Scholarships |
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