Abstract
Co-chaperones of the Hsp40 (or DnaJ) family play a key role in the maintenance of proteostasis. The main functions are: 1) recognition and binding of partially folded proteins; 2) delivering these proteins to Hsp70, which aid in folding; and 3) concomitant stimulation of ATPase activity of Hsp70. Because they are involved in recognizing several different proteins, there are more represent…