Abstract
Malignant melanoma is type of cancer with high death rates due, in part, to its propensity to form metastases. Approximately 90% of melanoma cases maintain wild-type p53 and perhaps this could be used as a tool to drive expression from the vector interest. Viral Vector Group (VVG - Incor - FMUSP) has developed adenoviral vectors in which transgene expression is controlled by the transcrip…